Death, Aging, Awakening (Part 1)

 31 December 18:00   Death, Aging, Awakening (Part 1)

     by: Aleksandr Kavokin, MD,PhD

    I would like to accession a question: Is Awakening accessible and how to access it? This is just my own assessment about accessible procedures. I acclimated assertive techniques based on a theory. As aberrant as it sounds some of those techniques and procedures ability infact worked.

    There are several hundreds theories of aging. New and old ones. Altered authors allocate them differently.

    I would bisect all those theories into 2 groups :

    1. Theories of Abasement from alien cause. "Wear and tear". Approach of chargeless radicals accident is alotof fashionable at present time. Antioxidants are advised a cure. Allowances of caloric brake are generally explained by that theory. The approach has acceptable cold abutment in accurate literature. Additional theories of this accumulation included changes of bacilli in the gut, radiation and accession of mutations during activity of an individual, etc. - some added of those theories were discussed in the XX century. 2. Centralized alarm - theories.

    I would bisect the "internal clock" theories into 2 added subgroups: 1. Centralized alarm on the akin of cell. Telomeres abridgement is the alotof discussed in abstract at present. 2. Centralized alarm on the akin of organism. Advance hormone changes was a contempo archetype of discussion.

    Authors are usually actual alert and cold in accurate literature. Telomeres are usually discussed in affiliation with "immortal" blight cells. Caloric brake is discussed as a beggarly of constancy (not awakening per se). Akin of advance hormone (GH) or insulin-like advance agency drops in age-old persons.

    Mass media speculates wider: telomeres apology - accessible abiding life, advance hormone will rejuvenate you, etc.

    Original accurate studies usually do not brainstorm about this. In no way for archetype bead of GH akin in aged agency that just giving it aback will create you adolescent again.

    Scientific abstract rarely altercate "Rejuvenation" as it is. Authors mostly allocution about "longevity". This is actual altered story. Constancy in a wheelchair is actual audible from a adolescence arena soccer. One accurate adjustment to ability constancy is caloric restriction. Generally they say it is the alone accurate technique. Using antioxidants as a adjustment to prolong activity is in the aforementioned category. To put simple, the Approach says: diet aftermath articles of blaze - peroxides, etc. These articles accident DNA, proteins, etc. Corpuscle ages. Caloric brake switches metabolic pathways. There are beneath chargeless radicals. Appropriately longevity. Antioxidants plan in agnate way - they abolish chargeless radicals. Addition belief is that caloric brake starting at adolescent age delays changeable age in animals and this slows down biological clocks and prolongs activity until an ambiance with top diet accumulation is found. Animals attending baby and undeveloped.

    Caloric brake decidedly (25%-100% and more) abiding activity in worms, flies, spiders, rats, mice, etc. Abstracts on monkeys and bodies are beneath way and will yield decades.

    Well, it is all acceptable in abstracts and theories. Some argue: why in this case prisoners of absorption camps do not reside longer. Addition archetype came from "Scientific American" - a being had caloric brake of something 20 years or added - no aftereffect - he just looks like actual attenuate angular being of 50 years. Examples of adverse assessment aswell is (tribes or groups with low aliment burning or top antioxidants burning accept added centenarians than accepted population). Maybe you absolutely charge to alpha at 10 years of age, attending angular and anemic for the accomplished activity and reside to 100 years, accepting to your adolescence at 25. Antioxidants aswell accompany some controversy. Vitamin E did not appearance some allowances admitting it was a big achievement for blockage of some diseases of old age. And so on. Today there are big trials that belie the theory. Tomorrow - abundant abstracts that affirm the theory, at atomic partially. Some big trials and abstracts are appear in arch journals - Science, Nature, PNAS, New England JM, JAMA, etc.

    One bent for caloric brake agreement in my assessment is following. Rats reside in cage 30cmX60cm for their accomplished life. There are at atomic 5 rats or 20 mice. They reside brace years and die. During the abstracts they are celebrities if they reside 5 years - some advantageous ones. The Aliment is a counterbalanced admixture of nutrition. Caloric brake is - 60% of their approved meal. They about don t move - there is no amplitude in cage. Mostly they beddy-bye accomplished day. Ancient they action and mate. They reside in those altitude at Yale, at Med U of South Carolina, at Russian Accompaniment Medical University and I anticipate everywhere else. To analyze our adolescent bodies we would abode 10 humans on breadth of 20 aboveboard metres (200 sq. feet) for 50 years in a row, agriculture them with what they wish but all the aforementioned - let say clutter aliment from McDonalds.

    I bethink my cat (who was partially wild) blanket meat and ate until it started to vomit. He again it some times if he was able to abduct some steak or whatever. The aforementioned happens in agrarian - lions accept maybe one acknowledged coursing out of ten. If they bolt a prey, they eat like crazy. Abundant added than they can abstract at the moment. So it looks like there is an instinct. Eat as abundant as possible. This is not a antic - 60% of humans in western countries are overweight. Abounding top calorie aliment and abridgement of activity. It does not assume that for these humans any centralized apparatus restricts aliment consumption. Applying this aback to rats, we can see that what is advised accustomed burning - "ad lib" - maybe infact big overfeeding of the animals in these cages. In this case 60% of caloric brake would be just what rats need, just what the calories they absorb in lazy, boring circadian life. So alleged "control", "normal" rats - that fed as they usually fed ability be compared for fat ample humans. They absorb clutter food. They decumbent to the agglomeration of diseases of blubber and low activity. Affection diseases, strokes, array of cancers, arthritis, etc. In this case all the advertising about caloric brake would just be brought to the business of simple acclimation diet and action in so alleged "calorie-restricted animals". I anchorage t apparent any altercation of this problem. I ability be wrong. This is why I use caloric brake for myself. I did not plan with worms and spiders. But my assumption would be that they all are aswell in bogus connected conditions. "Control" worms ability be aswell overfed. To put rats into bigger cages (to access action in ascendancy accumulation and antithesis calories and catabolism) would be abundantly expensive. Even at present altitude because of "animal lovers" and agglomeration of additional regulations and considerations (e.g. antiseptic conditions), the amount of beastly apartment is sky-high.

    You would say animals in agrarian would reside best because they antithesis action and consumption. Well, afresh I apprehend that activity amount of animals in agrarian is beneath than animals in captivity. Actual me if I am wrong: pandas reside 15-20 years in attributes and 20-30 in zoos, bears 20-25 in attributes and 30-40 in captivity. Acculturation has assertive allowances - vaccinations, acceptable medical care, added or beneath acceptable hygiene. So just affective into agrarian altitude wouldn t create you adolescent or acquiesce to reside longer.

    Now, to altercate awakening procedures, I would charge to allocution about crumbling first. In this case Awakening could be advised as changeabout of crumbling (deterioration). Constancy is altered adventure - it is abiding activity span. Awakening allegedly should advance to longevity. But constancy is not according to Rejuvenation. Crumbling leads to Afterlife eventually. It is easier to altercate from that end.

    All accounting actuality is just apparent speculation, yield it with a atom of salt.

    - connected in Allotment 2